Metformin: A drug for Diabetes and friends with 2DG Summary Metformin is an antihyperglycemic drug, also used in the treatment of cancer nowadays. It has the ability to inhibit oxidative phosphorylation in cells. It also increases the expression of p53 in cells that induce apoptosis. If metformin is used in combination with 2DG, which […]
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Summary Different therapeutic modalities are used for the treatment of cancer patients. One of the important cures is the use of immunotherapy. In this therapy, different drugs, vaccines, or antibodies are given to the patient that will boost the immune system of a patient to act strongly against the tumors. But this therapy has many
Can 2DG make immunotherapy more effective? Read More »
Summary Chemotherapy is an essential therapeutic strategy used for many years to treat cancer patients. But the chemotherapeutic drugs used have many side effects on the patient body. The tumor size may get reduced after the treatment. But it reoccurs in the patient after some time. To overcome these limitations of Chemotherapy. We have discussed combining therapy, glucose antimetabolite called 2-deoxy-D-glucose, and Chemotherapy. This shows
Can 2-deoxy-D-glucose (2DG) make Chemotherapy more effective? Read More »
2-deoxy-D-glucose A glucose molecule in which a hydrogen atom replaces the 2-OH group is termed 2DG. It is a glucose analog but an inhibitor of the glycolytic pathway. 2DG binds the Glut transporters at the place of glucose, enters the cell, and accumulates there. It is converted into 2-deoxy-D-glucose 6 phosphate (2DG6P) by Hexokinase. Then
2DG foes Mannose and N-acetyl Cysteine (NAC) Read More »
