IMPACT OF HIGH-DOSE INTRAVENOUS VITAMIN C ON CANCERS WITH BRAF & KRAS MUTATIONS As soon as someone talks about winter, oranges are the first thing that comes into mind. These citrus fruits not only taste amazing but the vitamin C present in oranges has been found to have the potential to fight cancer. Scientific …
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Antisense BCL-2 and HER-2 Oligonucleotide Therapy in Breast Cancer HER2 Positive Breast Cancer Human Epidermal Growth Factor Receptor 2 (HER2) is involved in the growth & proliferation of breast cancer cells. The patients with breast cancer that are tested positive for HER2 are called HER2-positive breast cancer patients. They have extra copies of those …
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Role of Antisense Oligonucleotide Therapy in Pancreatic Cancer Antisense oligonucleotides Oligonucleotides are short sequences of nucleic acids either DNA or RNA that can bind complementary mRNA sequences in the nucleus and have the capability to inhibit the translation of mRNA in proteins. Oligonucleotides were discovered about 20 years ago to inhibit the RNA and …
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Chemosensitization by Antisense Oligonucleotides Targeting MDM2 Expression MDM2 gene MDM2 oncogene in humans encodes Mouse double minute 2 homolog or MDM2 protein. This protein negatively regulates a tumor-suppressive gene in the cell called P53. It also acts as an E3-Ubiquitin ligase protein that binds the N-terminal of the p53 protein and inhibits the transcriptional …
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Progesterone Antisense Oligonucleotides Inhibits Breast Cancer Growth Hormone status of breast cancer Breast cancer arises from the growth of an abnormal mass of cells across the breast tissues. When this tumor is examined, it may be sensitive to some female hormones like estrogen and progesterone. The cells in breast tumors have receptors for these …
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Antisense Oligonucleotide Therapy in Oncology Summary Antisense oligonucleotide therapy plays a vital role in cancer and genetic disorders. This therapy involves the use of oligonucleotides that are complementary to specific target DNA or RNA in the nucleus. Oligonucleotides bind the complementary sequence and inhibit the synthesis of specific proteins by different mechanisms. Thus, downregulating …
A Breakthrough in Cancer Treatment: How Successful is Antisense Oligonucleotides (ASOs) Oligonucleotides Small sequences of nucleic acids, either DNA or RNA that have many important applications in genetic research are called oligonucleotides. Antisense oligonucleotides (ASOs) These are designed in the laboratory having a specific sequence complementary to our sequence of interest. They bind …
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