Chemotherapy -

Chemotherapy is one of the most widely used treatments for cancer patients. Since the invention of modern medicine Chemotherapy has single-handedly been One of the most effective treatments for almost all types of cancers with results at times not even thought of before the invention of this field of medicine.

However, treating advanced or late stage cancer patients with chemotherapy has had its own sets of positive outcomes and challenges. At Art Of Healing Cancer, our experienced oncologist uses the right combination of the below knowledge to bring the best outcome for the cancer patients with at times either using combination therapies or by optimizing the dozing of the drugs.

Chemotherapy is a treatment used for cancer patients, it involves administering drugs / medicine through intravenous, intraperitoneal, oral or even intrathecal route to neutralize / kill cancer cells through various mechanisms including DNA Strand damage, blocking DNA multiplication, blocking enzymes that support healthy DNA or at times by interfering in the process of cell cycle. It acts on both local site as well as in metastatic sites and even on circulating tumor cells
Chemotherapy generally act against actively dividing cells, cancer cells by their inherent nature are multiply at much rapid rate than normal body cells. Therefore, they are more likely to be affected by chemotherapy drugs. But chemotherapy also damages healthy cells, especially those cells which have multiply to maintain body functions like bone marrow cells, gut epithelium, hair follicles, reproductive organs; which is why patients experience certain side-effects on chemotherapy
Common side-effects of chemotherapy include fatigue, nausea and vomiting, hair loss and an increased risk of infection, the side-effects vary depending on the type and dose of chemotherapy a patient receives as well as the overall general health condition of the patient

Types of Chemotherapeutic Agents

In advanced stage cancers, time to deliver the right treatment is key towards the survival of the patient, hence identifying the RIGHT DRUG AT RIGHT TIME becomes most important, which is where doctors at ART OF HEALING CANCER, focus the most. There are multiple chemotherapy drugs invented, researched and now available for the patients but broadly placed under the following Categories:

Alkylating Agents

These are a class of Anti-cancer chemotherapy drugs which act by inhibiting the Read more

Inhibitors of Topoisomerase

These are those classes of chemotherapy drugs that work by inhibiting the Read more

Epothilones & Nucleus Spindle Stabilizer

This category of chemotherapy agents works by Read more

Nucleoside Analogues

These are a large class of chemotherapeutic agents with the likes Read more

Identifying the right category and within the category, the right drug is key in advanced age cancers. Patients lose a lot of valuable time in case a drug does not work and hence the disease progresses.

Dosing and Administration

Chemotherapy is often administered in a different way to late stage cancer patients. This is because the side effects of the drugs can be more severe, and it is important to minimize these as much as possible.

Dosing

Appropriate dosing of the drug is most important in treating advanced stage cancers. Patients with advanced disease are morbid and weak. The dose and spacing has to take into account patient tolerance and its efficacy in cancer control. A right balance between dosing of the drugs and the right spacing between sessions is key in advanced stage cancers.

Administration

Depending on the type of cancer, location of metastasis, organ involvement, physical condition of the patient and at times also their disease burden, the mode of administration of chemotherapeutic drugs might differ as following

  • Oral: Generally Low Dose and used as maintenance or Palliative Care
  • Systemic IV: Low Dose or High Dose, to be used multiple factors as explained above.
  • Loco Regional: There are multiple modalities of how a loco regional chemotherapy can be given depending on various factors involving location of metastasis, organ involvement including other factors. At Art of healing cancer, we are working towards developing extensive expertise around HIPEC, PIPEC, TACE, TACP & Electrochemotherapy

Chemotherapy sensitivity testing and analysis

At Art Of Healing Cancer, as explained above, we believe that identifying the right drug at the right time plays an important role in advanced cancers, hence chemosensitivity testing plays an important role in this regard.

Chemosensitivity analysis: The Circulating tumor / stem cell is identified, retrieved and grown in vitro by 3 D cell culture. All the available chemotherapy drugs, targetted and immunotherapy are tested for their inhibition of cancer. The reports are generally given in percentage ate of inhibition. This helps the Oncologist to choose the appropriate drug / drug family / drug combination.

 Please ask for the same while getting treated at Art of Healing Cancer.

Chemotherapy Resistance

Chemo residence is a big challenge for patients having advanced stage / recurrent cancers. Cancerous cells that are resistant to chemotherapy can survive and proliferate, making the cancer much harder to treat.

Fortunately, doctors at Art of Healing Cancer have been researching to understand the science of chemo and various other drug resistance and are working hard to develop new treatment modalities to overcome this obstacle while making the current treatments much more effective for a vast variety of cancers. Some of the mechanisms identified by our researchers include Tumor Hypoxia, Altered Cancer Metabolism, Overexpression of MDR & MRP Proteins, Overexpression of Anti Apoptotic Genes like BCL2 including few others. Their cutting edge approach combines conventional cancer therapies with some of the integrative treatment options such as off label drugs, Ayurveda, Phytochemicals, certain modalities like HBOT, hyperthermia, High Dose IV Vitamin C to overcome these factors. In this way every effort is made to make chemotherapy effective