What is Next Generation Sequencing (NGS)?
The Next Generation Sequencing Test is a powerful tool that can help you determine the best course of action for your cancer treatment. This test can provide your doctor with critical information about the specific genetic makeup of your tumor, which can help guide treatment decisions.
Next generation sequencing (NGS) is a newer type of DNA sequencing technology that allows us to sequence large amounts of DNA much faster and more cheaply than traditional methods. This means that we can now sequence an entire human genome in just a few days, whereas it used to take months or even years.
NGS has already revolutionized cancer research and diagnostics, and is now beginning to impact clinical care. The use of NGS to guide cancer treatment is known as precision medicine.
Precision medicine is an approach to disease treatment that takes into account the unique genetic makeup of each patient. By understanding the specific mutations that are driving a patient’s cancer, we can tailor treatments to target those mutations and potentially improve outcomes.
Germline mutations are changes to an organism’s DNA that are passed down from parent to offspring. These mutations can be beneficial, neutral, or harmful.
Beneficial germline mutations may confer a competitive advantage and help an organism survive and reproduce in its environment. For example, a mutation that confers resistance to a deadly disease may allow an individual to survive and pass on the mutation to their offspring.
Neutral germline mutations do not have any noticeable effect on an organism’s fitness. Many of these mutations occur in regions of the genome that do not code for proteins, or they may have such minor effects that they are not detectable.
Harmful germline mutations can decrease an organism’s fitness and reduce its chances of survival and reproduction. These mutations can cause developmental defects, diseases, or death. Some harmful mutations may only have a small effect on fitness, while others can be lethal like leading to development of Cancer