Metformin: A drug for Diabetes and friends with 2DG Summary Metformin is an antihyperglycemic drug, also used in the treatment of cancer nowadays. It has the ability to inhibit oxidative phosphorylation in cells. It also increases the expression of p53 in cells that induce apoptosis. If metformin is used in combination with 2DG, which […]
Metformin: A drug for Diabetes and friends with 2DG Read More »
PARP is a family containing many proteins that have important functions in the cell like the stability of the genome, repair of damaged DNA, and apoptosis or programmed cell death. PARP family members There are 17 proteins in this family. PARP 1 was the first protein from this family that was studied in detail.
Summary Different therapeutic modalities are used for the treatment of cancer patients. One of the important cures is the use of immunotherapy. In this therapy, different drugs, vaccines, or antibodies are given to the patient that will boost the immune system of a patient to act strongly against the tumors. But this therapy has many
Can 2DG make immunotherapy more effective? Read More »
Introduction Cancer cells have many hallmarks that differentiate them from normal cells. One of them is that the malignant cells have a high glucose metabolism rate as compared to those of normal cells. Because tumor cells have increased proliferation ability and growth rate, they need more energy in the form of ATP. Hence, they use more glucose to produce ATP
Can 2-deoxy-D-glucose (2DG) Make Radiation Therapy More Effective Read More »
Summary Chemotherapy is an essential therapeutic strategy used for many years to treat cancer patients. But the chemotherapeutic drugs used have many side effects on the patient body. The tumor size may get reduced after the treatment. But it reoccurs in the patient after some time. To overcome these limitations of Chemotherapy. We have discussed combining therapy, glucose antimetabolite called 2-deoxy-D-glucose, and Chemotherapy. This shows
Can 2-deoxy-D-glucose (2DG) make Chemotherapy more effective? Read More »
Summary Cancer is not a result of a single genetic alteration, but it occurs when there are many mutations in a genome. It does not depend only on the genomic mutations but also on some other factors that stimulate the tumors to result. The genetic alterations vary in different types of cancer and even in
How every cancer cell has different genetic mutations but common glucose metabolism Read More »
Cancer cells have some important hallmarks, one being aerobic glycolysis or increased glucose metabolism compared to normal cells. It is essential to control the glucose metabolism in these cells to prevent the metastasis of cancer cells around the neighboring tissues. Because glucose is an integral component for cell proliferation, cancer cells cannot proliferate and hence
