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November 7, 2022

Role of Antisense Oligonucleotide Therapy in Pancreatic Cancer

Role of Antisense Oligonucleotide Therapy in Pancreatic Cancer

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Role of Antisense Oligonucleotide Therapy in Pancreatic Cancer   Antisense oligonucleotides Oligonucleotides are short sequences of nucleic acids either DNA or RNA that can bind complementary mRNA sequences in the nucleus and have the capability to inhibit the translation of mRNA in proteins. Oligonucleotides were discovered about 20 years ago to inhibit the RNA and […]

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Chemosensitization by Antisense Oligonucleotides Targeting MDM2 Expression

Chemosensitization by Antisense Oligonucleotides Targeting MDM2 Expression

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Chemosensitization by Antisense Oligonucleotides Targeting MDM2 Expression   MDM2 gene MDM2 oncogene in humans encodes Mouse double minute 2 homolog or MDM2 protein. This protein negatively regulates a tumor-suppressive gene in the cell called P53. It also acts as an E3-Ubiquitin ligase protein that binds the N-terminal of the p53 protein and inhibits the transcriptional

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