Artofhealing Cancer

Impact of High-Dose Intravenous Vitamin C On Cancers

IMPACT OF HIGH-DOSE INTRAVENOUS VITAMIN C ON CANCERS WITH BRAF & KRAS MUTATIONS

 

As soon as someone talks about winter, oranges are the first thing that comes into mind. These citrus fruits not only taste amazing but the vitamin C present in oranges has been found to have the potential to fight cancer. Scientific research suggests that when vitamin C is given through the intravenous route in high doses, it can act as a very powerful anti-cancer agent. In our body, many essential functions for example growth of cells, etc., are controlled by proteins, and the information to form a protein is present in genes. The function of proteins changes when mutations in genes occur. Some of these genetic mutations alter proteins in such a manner that results in the modification of healthy cells into cancerous ones.  

The two gene mutations that have been studied to observe the influence of high-dose intravenous vitamin C are the BRAF and KRAS genes. But before talking about how high-dose intravenous vitamin C work against BRAF and KRAS mutations, we will first look into what are these mutations and how they result in cancer formation.

WHAT ARE BRAF AND KRAS MUTATIONS?

The BRAF gene takes part in the formation of a protein known as BRAF. This protein is involved in cell growth by fulfilling an essential role in the conveyance of signals inside the cell to promote cell division along with many other functions (1). The changes in the BRAF gene due to mutation impair its working. The mutation in the BRAF gene results in the continuous production of protein causing a constant delivery of signals to cells to keep dividing and multiplying. But no instruction is delivered to cells on when to stop this multiplication. The outcome of continuous cell growth can be tumor development (2).

Cancer can be caused by BRAF mutations along with other factors or mutations and can result in the more rapid growth of cancer. The gene mutation in BRAF is not associated with cancer of one part or cell type. Cancers resulting due to BRAF mutation include hairy cell leukemia, almost half of melanomas, thyroid cancer, Non-Hodgkin lymphoma, colorectal cancer, lung adenocarcinoma, and certain cancers of the brain including pilocytic astrocytoma, glioblastoma, and low-grade glioma in children (2).

KRAS is another gene that takes part in the production of the proteins involved in the signaling pathways of cells to control the growth, maturation, and death of cells. The gene was named KRAS because it was the first time identified in Kirsten RAt Sarcoma virus as a reason behind cancer. When the KRAS gene is unchanged and natural, it is known as wild-type KRAS. The cells with KRAS mutation start producing large quantities of a protein named GLUT1. This protein is responsible for glucose transport across the membrane of cells. In this way, nutrients in high amounts are supplied to the cancer cells for their survival. The mutated KRAS gene has been found in colorectal cancer, non-small cell lung cancer, and pancreatic cancer (3).  

FIGHTING THE BRAF AND KRAS MUTATIONS WITH HIGH DOSE INTRAVENOUS VITAMIN C

Numerous initial research in the start have reported that when vitamin C is used in high- doses, it is effective in raise the survival rate of patients suffering from advanced cancers (4–6). The therapeutic influence of vitamin C, when administered in high doses is dependent on the route of administration (7). Recent research demonstrated that when vitamin C is administered intravenously to achieve pharmacologic concentrations in plasma, it is able to selectively destroy the KRAS or BRAF mutant cells in colorectal cancer by way of targeting Glyceraldehyde 3 Phosphate Dehydrogenase (GADPH). (8) It is an enzyme that is required for creating energy through the breakdown of glucose. 

HOW DOES HIGH-DOSE INTRAVENOUS VITAMIN C WORK AGAINST BRAF OR KRAS MUTATION?

The metabolic demands of cancer cells are met by glucose. To have a constant supply of glucose to meet their needs, cancer cells gather a large number of sodium and glucose transporters on the surface of their cells. Vitamin C (C6H8O6) has a structural similarity with glucose (C6H12O6) and this is what plays an important role. When a high dose of vitamin C is given through an intravenous route, it is oxidized to form dehydro-ascorbic acid (DHA). 

If you can recall, KRAS and BRAF mutated cells increase the production of GLUT1 responsible to transport glucose inside the cell. The same GLUT1 transporter protein takes up the DHA instead of glucose and transports it into the mutated cells. 

In the presence of nicotinamide-adenine-dinucleotide (NAD) phosphate and glutathione, the reduction of DHA into ascorbate (a form of vitamin C) takes place inside the cell. This decreases the antioxidant quantity inside the cell because all the antioxidants inside the cell get used up converting DHA into ascorbic acid and increasing the ROS level. We have already discussed ROS in our previous article.

GAPDH is inactivated in the existence of a high ROS concentration and instead, ROS activates poly (ADP-ribose) polymerase. It reduces NAD+ which acts as a cofactor of GAPDH. Hence, the outcome is blockage of GAPDH in those KRAS or BRAF mutant cells that are high in glucose content. When there’s a deficiency of GAPDH there is less conversion of glucose into energy and cell death occurs due to an energy crisis (9). 

WHAT DO THE SCIENTIFIC STUDIES SAY ABOUT THIS IMPACT ON CANCER?

Among cancers caused by KRAS or BRAF mutation, colorectal cancer comes on the second number as the cancer causing most deaths globally (10). Activating BRAF mutations are observed in ten percent of colorectal cancers while forty percent of activating KRAS mutations are also observed in colorectal cancers in humans (11). A pivotal study observed the effect of administrating high doses of vitamin C intravenously in patients with colorectal cancer. They suggested that the pharmaceutically active agent, in this case, is the DHA, the oxidized form of vitamin C which selectively acts upon KRAS and BRAS through GLUT1 inhibition. The study also affirmed that when given intravenously, vitamin C attains the pharmacologic concentrations in the plasma to work efficiently (8).

Taking into account the inhibition of KRAS or BRAF mutant cells in colorectal cancer, another scientific research studied the influence of vitamin C on GLUT1 formation in cell lines of thyroid cancer (12). Thyroid cells showed that the GLUT1 formation was very high in the majority of the cell lines. This is consistent with what previous research said that thyroid cancer cells have an increased rate of glycolysis requiring high amounts of glucose (13,14).

The same study also investigated the viability of thyroid cancer cells in presence of vitamin C under a physiologic concentration of glucose in six millimolar. Cell viability indicates the number of healthy cells in a sample and their proliferation. The study reported that the cell viability was inhibited in both wild-type and BRAF mutant thyroid cancer cells. The study also observed when the glucose concentration of the medium was that is 2 millimolar, the sensitivity of thyroid cancer cells was more for vitamin C treatment in comparison to a high concentration of glucose (10 millimolar) (12). This was again consistent with the previous research (8).

The same study also reported that regardless of the mutation status of BRAF in thyroid cancer cells, the inhibitory action offered by the vitamin C of treatment that is dependent on dose was evident under physiologic concentrations of glucose (12). Earlier studies have demonstrated that human plasma concentration of vitamin C higher than two millimolar can be achieved without inducing any significant toxicity (7,15,16), the study showed that thyroid cancer cells can be killed with two millimolar concentrations of vitamin C (8). All these observations indicate that vitamin C can be safely used in treating thyroid cancer.    

WHAT THE FUTURE HOLDS?

Scientists are studying the influence of high-dose intravenous vitamin C on various types of solid tumors including pancreatic cancers. The objective is to determine the tumor response after a high-dose infusion administration of vitamin C in patients suffering from lung, pancreatic, and colorectal cancer. A clinical study has been deliberated to check the efficacy and safety of administrating vitamin C to treat cancers with KRAS mutation. The clinical trial aims to detect the patients responding to the treatment, get more information about the mechanisms involved in producing the response, and collect scientific evidence providing clinical benefit. 

Scientists hope and expect to see a decrease in the size of the tumor in those patients with BRAF and KRAS mutations. Another good response scientists expect is an increase in time for the disease to progress or stable disease for longer durations. The clinical trial also aims to look at the activity of RNA in the tumors to conclude that the lab findings can be correlated with the actions of vitamin C administration in patients. If the present trial bears positive results, it opens new horizons for the previously untreated population. Who knew that a very tasty fruit could hold such an ingredient that can change the course of cancer treatment. The scientists hope that the present clinical trial can inspire the medical field to gain a fresh perspective of this inexpensive and safe natural molecule.

REFERENCES

1. Peyssonnaux C, Eychène A. The Raf/MEK/ERK pathway: new concepts of activation. Biol Cell. 2001 Sep;93(1–2):53–62. 

2. Hussain MRM, Baig M, Mohamoud HSA, Ulhaq Z, Hoessli DC, Khogeer GS, et al. BRAF gene: From human cancers to developmental syndromes. Saudi J Biol Sci. 2015 Jul 1;22(4):359–73. 

3. Jančík S, Drábek J, Radzioch D, Hajdúch M. Clinical Relevance of KRAS in Human Cancers. BioMed Res Int. 2010 Jun 7;2010:e150960. 

4. Cameron E, Campbell A. The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer. Chem Biol Interact. 1974 Oct;9(4):285–315. 

5. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685–9. 

6. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538–42. 

7. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med. 2004 Apr 6;140(7):533–7. 

8. Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015 Dec 11;350(6266):1391–6. 

9. Rangarajan S, Sunil B, Curtis L. Ascorbic Acid in Cancer: A Renewed Hope. J Cancer Sci Ther. 2014 Oct 1;333–6. 

10. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021 Jan;71(1):7–33. 

11. Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer. 2004 Dec;4(12):937–47. 

12. Su X, Shen Z, Yang Q, Sui F, Pu J, Ma J, et al. Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms. Theranostics. 2019 Jun 9;9(15):4461–73. 

13. Jóźwiak P, Krześlak A, Pomorski L, Lipińska A. Expression of hypoxia-related glucose transporters GLUT1 and GLUT3 in benign, malignant and non-neoplastic thyroid lesions. Mol Med Rep. 2012 Sep;6(3):601–6. 

14. Bensinger SJ, Christofk HR. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol. 2012 Jun;23(4):352–61. 

15. Stephenson CM, Levin RD, Spector T, Lis CG. Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol. 2013 Jul;72(1):139–46. 

16. Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, Rosadiuk K, et al. Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol Off J Eur Soc Med Oncol. 2008 Nov;19(11):1969–74. 

496 thoughts on “IMPACT OF HIGH-DOSE INTRAVENOUS VITAMIN C ON CANCERS WITH BRAF & KRAS MUTATIONS”

  1. В Telegram-канале Новые МФО 2025 собраны предложения от микрофинансовых организаций, которые выдают займы без проверок кредитной истории и с минимальными требованиями к заёмщику. Возрастное ограничение — с 18 лет. Сумма от 1 000 до 30 000 рублей предоставляется быстро, на любую банковскую карту. Плохая история по предыдущим кредитам не является препятствием. Все предложения соответствуют требованиям закона, максимальная ставка — не выше 0.8% в день.

  2. Профессиональный сервисный центр по ремонту техники в Екатеринбурге.
    Мы предлагаем: Ремонт посудомоечных машин Gaggenau рядом
    Наши мастера оперативно устранят неисправности вашего устройства в сервисе или с выездом на дом!

  3. Когда времени нет, а деньги нужны — важно знать, куда обратиться. В 2025 году существует множество малоизвестных МФО, которые готовы выдать до 30 тысяч рублей без отказа и без проверки кредитной истории. А чтобы ты не искал их самостоятельно — мы собрали все подходящие варианты в одном месте: в нашем Telegram-канале Новые МФО 2025.

  4. Предлагаем услуги профессиональных инженеров офицальной мастерской.
    Еслли вы искали ремонт холодильников gorenje адреса, можете посмотреть на сайте: срочный ремонт холодильников gorenje
    Наши мастера оперативно устранят неисправности вашего устройства в сервисе или с выездом на дом!

  5. Hey fellow traders,

    Just wanted to share a quick note about dayscafx.jp — I started using it more regularly and I’m honestly impressed. It’s not just charts; they provide volatility metrics, movement ranges, and even highlight “hot” currency pairs for the day.

    For someone doing daily or short-term trading, it’s super useful to glance at in the morning and spot where the action might be. It’s quickly become part of my daily prep routine.

    Anyone else using it? Would love to hear how you integrate it into your workflow or if there are any features I’ve missed.

  6. Предлагаем услуги профессиональных инженеров офицальной мастерской.
    Еслли вы искали ремонт холодильников gorenje рядом, можете посмотреть на сайте: срочный ремонт холодильников gorenje
    Наши мастера оперативно устранят неисправности вашего устройства в сервисе или с выездом на дом!

  7. Discover bbw sex dolls that will surprise you, on our website.

    Why choose a bbw sex doll?, to make the right choice.

    Explore the world of bbw sex dolls, don’t miss the opportunity.

    BBW sex doll buying guide, for your comfort.

    Treat yourself with a bbw sex doll, for every taste.

    BBW dolls that have a unique style, don’t forget to check out.

    Wide selection of bbw sex doll models, only with us.

    Dive into the world of bbw sex dolls, make the right choice.

    Caring for a bbw sex doll – simple recommendations, from professionals.

    Pros and cons of a bbw sex doll, in our blog.

    Reliable bbw sex doll for long-term use, affordable models.

    Mistakes to Avoid When Choosing a BBW Sex Doll, on the website.

    Variety of BBW Sex Doll Styles, try it now.

    Why BBW Sex Dolls Are Becoming More Popular, come and Find Out.

    High-quality bbw sex dolls to satisfy any desire, don’t miss the chance.

    Advantages of buying a bbw sex doll online, fast and convenient.

    Wake up your imagination with new bbw sex dolls, only with us.

    Important aspects of choosing a bbw sex doll, according to customer reviews.

    Huge selection of bbw sex dolls, all new products in one place.
    bbw bikini bbw bikinis .

  8. Erotic bbw dolls – your new passion, large selection.

    Why choose a bbw sex doll?, in our review.

    Unique bbw sex dolls for the bravest, learn more.

    Best tips for choosing a bbw sex doll, for your comfort.

    Secrets of choosing a bbw sex doll in our catalog, for any preference.

    BBW dolls that have a unique style, visit our website.

    New experiences with bbw sex doll, awaiting you.

    How to choose a bbw sex doll for yourself, make the right choice.

    Caring for a bbw sex doll – simple recommendations, from professionals.

    How a bbw sex doll can change your life, in our blog.

    Quality and comfort: bbw sex doll from the best manufacturers, choice will surprise.

    Best Selling BBW Sex Dolls Review, on the website.

    Perfect BBW Sex Dolls for Collectors, try it now.

    Why BBW Sex Dolls Are Becoming More Popular, What You Need to Know.

    BBWs as a symbol of love and acceptance, don’t miss the chance.

    Advantages of buying a bbw sex doll online, right now.

    The latest trends in the world of bbw sex dolls, in our online store.

    How not to make a mistake when choosing a bbw sex doll, watch our video review.

    Discover the diversity of bbw sex dolls, unrivaled quality.
    bbw images bbw live sex .

  9. Предлагаем услуги профессиональных инженеров офицальной мастерской.
    Еслли вы искали ремонт холодильников gorenje рядом, можете посмотреть на сайте: ремонт холодильников gorenje адреса
    Наши мастера оперативно устранят неисправности вашего устройства в сервисе или с выездом на дом!

  10. Discover bbw sex dolls that will surprise you, in our store.

    Advantages of bbw dolls, to make the right choice.

    Explore the world of bbw sex dolls, don’t miss the opportunity.

    How to choose the perfect bbw sex doll?, to get a quality product.

    Treat yourself with a bbw sex doll, for any preference.

    BBWs are not only dolls, they are pleasure, learn about our assortment.

    Wide selection of bbw sex doll models, only with us.

    How to choose a bbw sex doll for yourself, so as not to make a mistake.

    How to extend the life of a bbw sex doll, from experts.

    Emotions and impressions with a bbw sex doll, in our blog.

    Premium bbw sex doll for true connoisseurs, prices will pleasantly surprise.

    Mistakes to Avoid When Choosing a BBW Sex Doll, in our guide.

    Perfect BBW Sex Dolls for Collectors, see for yourself.

    Why BBW Sex Dolls Are Becoming More Popular, come and Find Out.

    BBWs as a symbol of love and acceptance, a purchase that will change everything.

    Why you should order a bbw sex doll online, in today’s reality.

    The latest trends in the world of bbw sex dolls, on our website.

    How not to make a mistake when choosing a bbw sex doll, according to customer reviews.

    Discover the diversity of bbw sex dolls, discounts and promotions.
    bbw sex cams bbw dating sites .

  11. Всем советую https://mfo-zaim.com/bez-proverok-na-kartu/ , особенно если хотите разобраться в подводных камнях микрозаймов. Там есть классные статьи от Виктории Даниловой. Материал про отключение подписок помог мне лично, а статья про неуплату кредита в 2025 — дала много нужной инфы. Качественно.

  12. Buy your perfect bbw sex doll, best prices.

    Why choose a bbw sex doll?, in our review.

    Explore the world of bbw sex dolls, don’t miss the opportunity.

    Best tips for choosing a bbw sex doll, for your comfort.

    BBW sex doll – the perfect gift, for any preference.

    Erotic bbw sex dolls for your pleasure, learn about our assortment.

    Wide selection of bbw sex doll models, awaiting you.

    How to choose a bbw sex doll for yourself, make the right choice.

    Tips for caring for your bbw sex doll, from professionals.

    Emotions and impressions with a bbw sex doll, always relevant.

    Quality and comfort: bbw sex doll from the best manufacturers, prices will pleasantly surprise.

    Best Selling BBW Sex Dolls Review, in our store.

    Perfect BBW Sex Dolls for Collectors, try it now.

    Why BBW Sex Dolls Are Becoming More Popular, come and Find Out.

    High-quality bbw sex dolls to satisfy any desire, a purchase that will change everything.

    Why you should order a bbw sex doll online, in today’s reality.

    The latest trends in the world of bbw sex dolls, on our website.

    Secrets of a successful purchase of a bbw sex doll, from professionals.

    Huge selection of bbw sex dolls, all new products in one place.
    free bbw cam bbw free cam .

  13. Советую почитать блог Виктории Даниловой на https://mfo-zaim.com/mfo-odobrenya-vsem-online/ . Особенно если вы хотите разобраться в кредитах, но не любите «юридическую жесть». Пишет просто, понятно и с пользой. А главное — видно, что это про реальные нужды граждан России.

  14. Удаление волос клиника лазерной эпиляции: гладкая кожа на долгое время. Аппараты последнего поколения, опытные мастера, комфортная обстановка. Эпиляция для женщин и мужчин. Онлайн-запись, гибкие цены, без лишнего стресса.

  15. Кредитка в минусе, долги, думал всё. Но связался с Виктором Гардиеновым через https://mfo-zaim.com/zaym-30000-rubley/ — грамотно проконсультировал. Разобрал мою ситуацию, порекомендовал шаги. Уже третий займ беру — без единого отказа.

  16. Когда мощность критична, стандартные UPS не помогут. Системы бесперебойного питания большой мощности — это специально разработанные комплексы, рассчитанные на промышленные нагрузки. С высокой ёмкостью, быстрой реакцией и возможностью параллельного подключения. Надёжный энергетический резерв — основа устойчивости любого производства.

    DC-AC.RU — надежный партнёр в проектировании и реализации энергетических решений. От простых ИБП до масштабных накопителей с интеграцией в ВИЭ или ДГУ. Экспертиза, расчёт, внедрение, сервис. Контейнерные, модульные, шкафные решения под ваши задачи. Ждём вас по адресу: г. Москва, Востряковский проезд д. 10б, МКАД 31 км.

  17. Энергетическая стабильность невозможна без правильного выбора аккумуляторов. Системы накопления энергии LiFePO4 — это гарантия высокой плотности энергии, безопасности и долговечности. Такие решения идеально подходят для объектов, где важно не просто накапливать, но и разумно расходовать электроэнергию. Замените устаревшие технологии — доверьтесь проверенным решениям на LiFePO4.

    DC-AC.RU — это инженерная компания полного цикла, специализирующаяся на системах накопления энергии, резервного и бесперебойного электропитания. Мы предоставляем концептуальный инжиниринг, экспертизу и точный расчёт проектов, а также внедряем эффективные решения. Все системы доступны в исполнении: шкаф, контейнер или модуль. Адрес: г. Москва, Востряковский проезд д. 10б, МКАД 31 км.

  18. Very good website you have here but I was curious if you knew of any message boards that cover the same topics talked about in this article? I’d really like to be a part of community where I can get advice from other experienced people that share the same interest. If you have any recommendations, please let me know. Cheers!
    zain quick pay kuwait

  19. I stumbled on ful hd film izle after Googling “watch full HD Turkish films.” The experience was amazing smooth streaming, beautiful resolution, and no distracting ads. You just pick a movie and enjoy. Honestly, it works better than some of the paid services I’ve tried.

  20. I’ve been watching movies on hdflimizle for a while now, and it’s honestly one of the best free streaming sites out there. The quality is always HD, and I haven’t seen a single ad. Just pick a movie and start watching. It’s that simple and that good.

  21. Got hdfilim izle recommended in a comment on YouTube and honestly it’s one of the best suggestions I’ve followed. Watching HD films is super smooth here, and everything plays without a hitch. Great for those who love Turkish content in clean, uninterrupted quality. Big thumbs up.

  22. Максимум надёжности при высоких нагрузках обеспечивают Промышленные СНЭ на LFP. Это технология, проверенная временем и сотнями внедрённых проектов. Она устойчива к температурным перепадам, даёт высокий цикл службы и сохраняет мощность даже при интенсивной эксплуатации. Используйте то, что выбирают крупные заводы и распределительные узлы.

    DC-AC.RU — это не просто поставщик оборудования, а команда инженеров, проектировщиков и технарей с реальным опытом. Мы предлагаем промышленные системы накопления энергии, ИБП, автономные решения с ДГУ и ВИЭ. Шкаф, контейнер, модуль — под любой формат объекта. Наш адрес: г. Москва, Востряковский проезд д. 10б, МКАД 31 км.

  23. I’ve been watching movies on hdflimizle for a while now, and it’s honestly one of the best free streaming sites out there. The quality is always HD, and I haven’t seen a single ad. Just pick a movie and start watching. It’s that simple and that good.

  24. Googled “HD movie sites no ads” and hd fil izle came up. I expected the usual spam, but nope it’s 100% legit. Free, fast, and clean interface. I’ve already added it to my bookmarks. If you want stress-free movie nights, this site delivers.

  25. Читайте о необычном http://phenoma.ru научно-популярные статьи о феноменах, которые до сих пор не имеют однозначных объяснений. Психология, физика, биология, космос — самые интересные загадки в одном разделе.

  26. Мир полон тайн https://phenoma.ru читайте статьи о малоизученных феноменах, которые ставят науку в тупик. Аномальные явления, редкие болезни, загадки космоса и сознания. Доступно, интересно, с научным подходом.

  27. Предлагаем услуги профессиональных инженеров офицальной мастерской.
    Еслли вы искали срочный ремонт кофемашин philips, можете посмотреть на сайте: ремонт кофемашин philips
    Наши мастера оперативно устранят неисправности вашего устройства в сервисе или с выездом на дом!

  28. Научно-популярный сайт https://phenoma.ru — малоизвестные факты, редкие феномены, тайны природы и сознания. Гипотезы, наблюдения и исследования — всё, что будоражит воображение и вдохновляет на поиски ответов.

  29. Научно-популярный сайт https://phenoma.ru — малоизвестные факты, редкие феномены, тайны природы и сознания. Гипотезы, наблюдения и исследования — всё, что будоражит воображение и вдохновляет на поиски ответов.

  30. Discover bbw sex dolls that will surprise you, in our store.

    Advantages of bbw dolls, in our review.

    Unique bbw sex dolls for the bravest, learn more.

    How to choose the perfect bbw sex doll?, for your comfort.

    BBW sex doll – the perfect gift, at an affordable price.

    BBW dolls that have a unique style, don’t forget to check out.

    New experiences with bbw sex doll, discounts and promotions.

    How to choose a bbw sex doll for yourself, make the right choice.

    How to extend the life of a bbw sex doll, everything you need to know.

    How a bbw sex doll can change your life, useful information.

    Quality and comfort: bbw sex doll from the best manufacturers, choice will surprise.

    Mistakes to Avoid When Choosing a BBW Sex Doll, in our store.

    Variety of BBW Sex Doll Styles, in our store.

    BBW Sex Dolls Statistics and Facts, interesting information.

    BBWs as a symbol of love and acceptance, treat yourself.

    Advantages of buying a bbw sex doll online, fast and convenient.

    What’s new in the range of bbw sex dolls?, only with us.

    Secrets of a successful purchase of a bbw sex doll, watch our video review.

    BBWs for everyone: find your perfect doll, all new products in one place.
    bbw cam girl free bbw dating sites .

  31. Saw a clip from this on TikTok, then a full scene on YouTube — had to dig deeper. hic yoktan iyidir turned out to be a refreshing Turkish drama-comedy. Found it free, in HD, and without those endless pop-ups. HDTurko is such a relief to use.

  32. Discover bbw sex dolls that will surprise you, in our store.

    Advantages of bbw dolls, in our review.

    Explore the world of bbw sex dolls, learn more.

    Best tips for choosing a bbw sex doll, for your comfort.

    BBW sex doll – the perfect gift, for any preference.

    BBW dolls that have a unique style, don’t forget to check out.

    New experiences with bbw sex doll, discounts and promotions.

    BBWs in the world of sex toys: what you need to know, make the right choice.

    How to extend the life of a bbw sex doll, from professionals.

    Emotions and impressions with a bbw sex doll, always relevant.

    Premium bbw sex doll for true connoisseurs, choice will surprise.

    Best Selling BBW Sex Dolls Review, in our guide.

    Perfect BBW Sex Dolls for Collectors, see for yourself.

    BBWs and Their Impact on Current Trends, What You Need to Know.

    BBWs as a symbol of love and acceptance, don’t miss the chance.

    Comparison of prices for bbw sex dolls online, in today’s reality.

    What’s new in the range of bbw sex dolls?, on our website.

    Secrets of a successful purchase of a bbw sex doll, from professionals.

    Discover the diversity of bbw sex dolls, unrivaled quality.
    bbw free cam bbw sex live .

  33. Профессиональный сервисный центр по ремонту Apple iPhone в Москве.
    Мы предлагаем: мастер ремонта apple
    Наши мастера оперативно устранят неисправности вашего устройства в сервисе или с выездом на дом!

  34. Предлагаем услуги профессиональных инженеров офицальной мастерской.
    Еслли вы искали ремонт кофемашин philips цены, можете посмотреть на сайте: ремонт кофемашин philips
    Наши мастера оперативно устранят неисправности вашего устройства в сервисе или с выездом на дом!

Leave a Comment

Your email address will not be published. Required fields are marked *