Chemosensitization by Antisense Oligonucleotides Targeting MDM2 Expression

Chemosensitization by Antisense Oligonucleotides Targeting MDM2 Expression

Chemosensitization by Antisense Oligonucleotides Targeting MDM2 Expression   MDM2 gene MDM2 oncogene in humans encodes Mouse double minute 2 homolog or MDM2 protein. This protein negatively regulates a tumor-suppressive gene in the cell called P53. It also acts as an E3-Ubiquitin ligase protein that binds the N-terminal of the p53 protein and inhibits the transcriptional …

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