October, 2022 -

Month: October 2022

Can 2-deoxy-D-glucose (2DG) Make Radiation Therapy More Effective

Can 2-deoxy-D-glucose (2DG) Make Radiation Therapy More Effective

Introduction  Cancer cells have many hallmarks that differentiate them from normal cells. One of them is that the malignant cells have a high glucose metabolism rate as compared to those of normal cells. Because tumor cells have increased proliferation ability and growth rate, they need more energy in the form of ATP. Hence, they use more glucose to produce ATP …

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Can 2DG make chemotherapy more effective

Can 2-deoxy-D-glucose (2DG) make Chemotherapy more effective?

Summary  Chemotherapy is an essential therapeutic strategy used for many years to treat cancer patients. But the chemotherapeutic drugs used have many side effects on the patient body. The tumor size may get reduced after the treatment. But it reoccurs in the patient after some time. To overcome these limitations of Chemotherapy. We have discussed combining therapy, glucose antimetabolite called 2-deoxy-D-glucose, and Chemotherapy. This shows …

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How every cancer cell has different genetic mutations but common glucose metabolism

How every cancer cell has different genetic mutations but common glucose metabolism

Summary Cancer is not a result of a single genetic alteration, but it occurs when there are many mutations in a genome. It does not depend only on the genomic mutations but also on some other factors that stimulate the tumors to result. The genetic alterations vary in different types of cancer and even in …

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Can We Control Sugar (Glucose) Metabolism In Cancer Cells: Basics Of 2DG And Mechanism Of Action

Can we control Sugar (Glucose) metabolism in Cancer cells: Basics of 2DG and mechanism of action

Cancer cells have some important hallmarks, one being aerobic glycolysis or increased glucose metabolism compared to normal cells. It is essential to control the glucose metabolism in these cells to prevent the metastasis of cancer cells around the neighboring tissues. Because glucose is an integral component for cell proliferation, cancer cells cannot proliferate and hence …

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