AOHC Breast Cancer Chemotherapy Dosage Calculator
Comprehensive calculator for all major breast cancer chemotherapy drugs. BSA-based calculations with dose reduction options (100%, 75%, 50%, 20%) and precise carboplatin dosing using Calvert formula.
Important: All dosing calculations are for educational purposes only. Always verify with current protocols and consult with oncology team before administration. Dose modifications may be needed based on toxicity, organ function, and patient factors.
Patient Information
Body weight (kg).
Height (cm).
Age (years) – for carboplatin dosing.
For creatinine clearance calculation.
mg/dL – for carboplatin dosing.
BSA & Renal Function Results
Body Surface Area (BSA)—
Creatinine Clearance (CrCl)—
Dose Reduction Applied—
Patient Weight—
Patient Age—
CrCl calculated using Cockcroft-Gault formula. Carboplatin dosing uses Calvert formula: Dose = AUC × (CrCl + 25).
Drug Dosages
Anthracyclines
Taxanes
Alkylating Agents
Antimetabolites
Platinum Compounds
Other Agents
| Drug | Standard Dose | Calculated Dose | Schedule |
|---|---|---|---|
| Doxorubicin | 60-75 mg/m² | — | IV every 21 days |
| Epirubicin | 75-90 mg/m² | — | IV every 21 days |
| Liposomal Doxorubicin | 50 mg/m² | — | IV every 28 days |
Note: Maximum cumulative dose for doxorubicin: 550 mg/m². Monitor cardiac function (ECHO/MUGA).
| Drug | Standard Dose | Calculated Dose | Schedule |
|---|---|---|---|
| Paclitaxel | 175 mg/m² | — | IV every 21 days |
| Paclitaxel Weekly | 80 mg/m² | — | IV weekly |
| Docetaxel | 75-100 mg/m² | — | IV every 21 days |
| Docetaxel Weekly | 35 mg/m² | — | IV weekly |
| Abraxane (nab-Paclitaxel) | 260 mg/m² | — | IV every 21 days |
| Abraxane Weekly | 125 mg/m² | — | IV weekly x3, q4w |
Note: Premedicate for hypersensitivity reactions. Monitor for peripheral neuropathy.
| Drug | Standard Dose | Calculated Dose | Schedule |
|---|---|---|---|
| Cyclophosphamide | 600 mg/m² | — | IV every 21 days |
| Cyclophosphamide (oral) | 100 mg/m² | — | PO daily x14 days |
| Ifosfamide | 1200 mg/m² | — | IV daily x5 days |
Note: Ensure adequate hydration. Monitor for hemorrhagic cystitis with cyclophosphamide/ifosfamide.
| Drug | Standard Dose | Calculated Dose | Schedule |
|---|---|---|---|
| 5-Fluorouracil | 600 mg/m² | — | IV days 1,8 q28d |
| Capecitabine | 1250 mg/m² | — | PO BID x14d q21d |
| Methotrexate | 40 mg/m² | — | IV days 1,8 q28d |
| Gemcitabine | 1000 mg/m² | — | IV days 1,8 q21d |
Note: Monitor for mucositis, hand-foot syndrome (capecitabine). Leucovorin rescue may be needed with high-dose MTX.
Carboplatin Dosing (Calvert Formula)
| Target AUC | Calculated Dose | Schedule | Clinical Use |
|---|---|---|---|
| AUC 6 | — | IV every 21 days | Standard adjuvant |
| AUC 5 | — | IV every 21 days | Combination therapy |
| AUC 4 | — | IV every 21 days | Elderly/reduced function |
| AUC 2 | — | IV weekly | Weekly schedule |
Calvert Formula: Dose (mg) = Target AUC × (CrCl + 25). CrCl capped at 150 mL/min for safety.
| Drug | Standard Dose | Calculated Dose | Schedule |
|---|---|---|---|
| Cisplatin | 75 mg/m² | — | IV every 21 days |
Note: Monitor renal function, hearing, and neuropathy. Adequate hydration essential for cisplatin.
| Drug | Standard Dose | Calculated Dose | Schedule |
|---|---|---|---|
| Vinorelbine | 25 mg/m² | — | IV weekly |
| Eribulin | 1.4 mg/m² | — | IV days 1,8 q21d |
| Ixabepilone | 40 mg/m² | — | IV every 21 days |
| Mitomycin | 10 mg/m² | — | IV every 42 days |
Note: Monitor for specific toxicities. Eribulin: QT prolongation. Vinorelbine: severe constipation.
Safety Information
This calculator is for educational purposes only. It does not provide treatment recommendations.
- Always verify dosing with current institutional protocols and drug monographs.
- Carboplatin dosing: Requires accurate creatinine clearance. Consider capping CrCl at 150 mL/min.
- Dose modifications may be required based on organ function, performance status, toxicity, and prior treatments.
- Maximum doses and cumulative dose limits must be observed (e.g., doxorubicin 550 mg/m²).
References
| Drug Class | Key References |
|---|---|
| Carboplatin (Calvert Formula) | Calvert et al. J Clin Oncol 1989; BC Cancer protocols[web:65][web:71] |
| Anthracyclines | FDA prescribing information, BC Cancer Drug Manual[web:51][web:54] |
| Taxanes | NCCN Guidelines, European Medicines Agency[web:52][web:55] |
| Other Agents | Susan G. Komen Foundation, Clinical studies[web:67][web:70] |