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Best Price Pembrolizumab: Drug Details & Savings | Katras| Jharkhand| India
Drug Category
Immunotherapy
Drug name
Pembrolizumab
Complete Drug Name
Pembrolizumab Injection
Mode of Delivery
Injection
Brand
Brand name: Keytruda Manufacturer: Merck & Co., Inc.
Dosage/Dose
Dosage of Pembrolizumab: 200mg via IV infusion, Q3W (every 3 weeks)
Types of Cancer & Indication
Pembrolizumab is authorized for treating various cancer forms, such as melanoma, non-small cell lung cancer, head and neck squamous cell carcinoma, classical Hodgkin's lymphoma, urothelial carcinoma, stomach cancer, esophageal cancer, and tumors exhibiting microsatellite instability or defective mismatch repair. This drug's purpose involves harnessing the immune system to boost the body's anti-tumor defenses.
Mechanism of Action
Pembrolizumab represents a cutting-edge immunotherapy approach, aimed at harnessing a patient's immune system to identify and attack cancerous cells. Its mode of action involves obstructing the PD-1 protein utilized by cancer cells to elude immune responses. With this interference, pembrolizumab enables immune cells to detect and eliminate malignant cells. Demonstrating remarkable adaptability, this treatment has exhibited success across diverse cancer forms, signifying a transformative development in cancer therapy.
Mechanism of Resistance
Resistance to pembrolizumab injection occurs when cancer cells adapt their molecular architecture to dodge immune checkpoint blockade, leading to hindered T-cell engagement, diminished display of tumor antigens, and amplified inhibitory components. This obstructs pembrolizumab's capacity to work effectively, lessening its potency against cancer.
Side Effects
Administering Pembrolizumab injection may lead to various side effects, including exhaustion, persistent cough, queasiness, and itchiness. In some cases, it may trigger intense outcomes, such as autoimmune assaults on normal organs, pulmonary irritation, hepatic difficulties, or critical infusion complications. Consistent supervision is crucial for early identification of these problems.
Combination Therapy
Pembrolizumab may be utilized in conjunction with several therapeutic agents, based on the particular cancer diagnosis. For example, non-squamous non-small cell lung cancer (NSCLC) treatment frequently involves the blend of pemetrexed, a platinum-based chemotherapy drug (either cisplatin or carboplatin), and pembrolizumab. Moreover, the FDA has sanctioned pembrolizumab's co-administration with axitinib to manage progressive renal cell carcinoma (RCC). It is crucial to seek a medical expert's guidance for tailored treatment choices.
Final Cost
Average price of Pembrolizumab Injection: ₹73,000 in India. The above price is specific for Katras, Jharkhand, India