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Art of Healing Cancer (AOHC India): A Comprehensive Guide to Integrative Cancer Treatment
Welcome to the Art of Healing Cancer (AOHC India), where we explore the world of cancer treatment through a holistic and integrative approach. In this comprehensive guide, we will delve into the intricate aspects of cancer, focusing on genes involved, intravenous Vitamin C (IVC) therapy, and nutraceuticals that can inhibit cancer-related genes. Our mission is to provide you with accurate and well-researched information to empower you in your journey to fight cancer.
Understanding Cancer
Cancer is a complex disease that affects millions of people worldwide. It is characterized by the uncontrolled growth and division of abnormal cells within the body. Cancer can manifest in various forms, such as breast cancer, lung cancer, prostate cancer, and many others. AOHC India is dedicated to shedding light on all types of cancer and their unique challenges.
Cancer and Ascorbic Acid: A Natural Approach to Tumor Reduction
Cancer remains a widespread and life-threatening disease affecting millions of individuals worldwide. Traditional treatments such as chemotherapy and radiotherapy are commonly employed in the fight against cancer. However, in recent years, the potential role of ascorbic acid, commonly known as vitamin C and naturally found in citrus fruits, has garnered attention in cancer management due to its antioxidant properties and various crucial functions in the human body.
Mechanism of Action
High-dose intravenous Vitamin C (IVC) therapy has gained recognition as a potential adjunctive treatment for cancer. IVC involves the administration of Vitamin C directly into the bloodstream, bypassing the digestive system. This method allows for higher levels of Vitamin C to be delivered to the body’s cells, potentially enhancing its anti-cancer effects.
Vitamin C, also known as Ascorbic Acid (AA) or Ascorbate, is a vital organic molecule crucial for normal metabolic processes in the body. It serves as a water-soluble vitamin with antioxidant properties and plays a role as a cofactor in various enzymatic reactions. Humans rely on dietary sources of vitamin C due to a genetic mutation that impairs its synthesis.
Ascorbic Acid, the reduced form of vitamin C, undergoes metabolism in the body. After ingestion, vitamin C is transported into cells through specific transporters or GLUT transport. Within cells, it is converted back to ascorbic acid. Subsequently, vitamin C degradation leads to the formation of end products such as carbon dioxide, oxalic acid, and L-erythrose, which are eventually excreted through the kidneys.
Vitamin C, also known as ascorbic acid, is an essential micronutrient for humans due to our inability to synthesize it. Among the many dietary antioxidants, ascorbic acid stands out for its potent antioxidant properties. In the 1950s, there was initial optimism that vitamin C could prevent cancer. However, in the 1970s, Linus Pauling and Ewan Cameron suggested a potential therapeutic role, citing improved survival rates in advanced-stage cancer patients who received high-dose intravenous vitamin C (IV Vit C) treatment. Subsequently, multiple randomized controlled studies (RCTs) employing large oral vitamin C doses failed to replicate these benefits, raising doubts about the treatment’s efficacy.
Recent literature highlights a crucial factor: the limited absorption rate of oral vitamin C in the stomach. This limitation necessitates intravenous or intraperitoneal administration to achieve the significantly elevated plasma concentrations required for therapeutic purposes. Human plasma concentrations resulting from high-dose IV vitamin C can be approximately two hundred times higher than those achieved through oral vitamin C treatment. Consequently, it is essential to recognize that high-dose vitamin C treatments administered orally and intravenously represent distinct therapeutic approaches with varying potential benefits.
High-Dose IV Vitamin C: Boosting Immunity for Enhanced Anti-Tumor Response
Role of Vitamin C in Immunity
Vitamin C, a potent antioxidant, plays a pivotal role in fortifying the body's immune system. It acts as a cofactor for essential enzymes involved in critical signaling pathways. Vitamin C accumulates in immune cells, generating reactive oxygen species (ROS) and Fe+2 species, contributing to cell elimination.
Enhancing Cancer Treatment
Vitamin C can combat resistance to anti-cancer drugs, making it a valuable addition to cancer therapy. It sensitizes tumor cells to conventional treatments like cisplatin, paclitaxel, and doxorubicin. Furthermore, it synergizes with radiotherapy and chemotherapy by reducing resistance mechanisms often seen in cancer cells.
Role of Vitamin C in Chemokines Production
Vitamin C modulates the immune response against cancer by promoting the production of cytokines and chemokines. It boosts Treg cell function through the TET mechanism and enhances natural killer cell activity.
Experimental Findings
In vivo and in vitro experiments highlight vitamin C's potential in fortifying Treg cells and natural killer cells to combat various cancers, suggesting its effectiveness as a cancer treatment.
Effects on Cancer Cells
High-dose IV Vitamin C has garnered attention for its potential in eradicating cancer cells, supported by several mechanisms:
- Tumor cells adapt to low oxygen levels by activating the transcription factor HIF-1. Vitamin C regulates HIF hydroxylases, leading to decreased HIF-1 activity, which has been observed in tumor samples.
- Vitamin C acts as an antioxidant, countering oxidative damage and apoptosis. It also reacts with oxidized vitamin E, restoring it to its native form.
- In high concentrations, intravenous vitamin C can act as a pro-oxidant, generating hydrogen peroxide-dependent cytotoxicity in cancer cells while sparing normal cells. This is achieved through redox reactions with metals like iron and copper, which are abundant in cancer cells.
- Vitamin C’s role as a reducing agent for iron is crucial for functions such as mitochondrial respiratory chains, collagen synthesis, and oxidative stress regulation.
- Vitamin C stabilizes collagen crosslinks, inhibiting neoplastic invasion. It also reverses epithelial mesenchymal transition (EMT) and reduces cell migration by deactivating HIF.
- High-dose vitamin C enhances the effectiveness of various chemotherapeutic agents in pre-clinical models, often by increasing the production of reactive oxygen species.
- Vitamin C affects immune cells by influencing processes like differentiation, polarization, cytokine production, chemotaxis, and enhancing natural killer (NK) cell activity. It also plays a role in regulating the epigenetic profile of immune cells.
Combining Intravenous Vitamin C and Fasting-Like Diet for Cancer Treatment
High-dose intravenous vitamin C (IVC) has emerged as a safe and promising anti-cancer therapy, either as monotherapy or in combination with conventional treatments. It improves patient quality of life and mitigates chemotherapy-related side effects. When paired with a fasting-like diet, vitamin C exhibits enhanced potential against cancer. Animal trials demonstrate slowed tumor growth and, in some cases, disease remission, particularly in colorectal cancer models. The combination addresses previous challenges, making vitamin C more detrimental to cancer cells by reducing protective ferritin levels. Ongoing clinical trials explore this approach in various cancer types, presenting an innovative and well-tolerated strategy. Additionally, fasting-mimicking diets offer multiple health benefits, including weight loss, cardiovascular health improvement, and potential cancer treatment support, enhancing overall well-being.
High-Dose Vitamin C Suppresses VEGF Expression in Cancer
A study explored the anti-cancer effects of high-dose vitamin C (VitC) on vascular endothelial growth factor (VEGF) expression in mice with Colon 26 rectal cancer xenografts. Administering high-dose VitC led to reduced VEGFA and VEGF D levels, decreased tumor volumes, and lowered levels of reactive oxygen species and HIF-1α. This research suggests that high-dose VitC inhibits tumor angiogenesis, contributing to its anti-cancer properties.
High-dose intravenous Vitamin C as Adjunctive Therapy to Chemo and Radiation
Several epidemiological studies highlight the potential anti-cancer benefits of vitamin C, which plays essential roles in various bodily functions. While animal studies have shown that oral vitamin C supplements can impede tumor development, higher doses than those achievable through diet are often needed for cancer management. Intravenous (IV) vitamin C has been used for years as a complementary cancer therapy. Concerns about its antioxidant nature potentially interfering with chemotherapy have been raised, but research indicates that IV vitamin C can sensitize cancer cells to radiation and chemotherapy while sparing healthy cells. Clinical studies have reported increased survival rates and tumor regression when IV vitamin C is combined with standard cancer treatments. Overall, IV high-dose vitamin C shows promise as an effective adjunctive anti-cancer therapy.
High-dose vitamin C Infusion and G6PD Deficiency
Vitamin C, known for its antioxidant properties, plays a crucial role in various bodily functions. However, high-dose intravenous vitamin C can lead to hemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, a genetic condition affecting red blood cell health. G6PD is essential for maintaining the lifespan and function of red blood cells, protecting them from oxidative stress. In G6PD-deficient individuals, the absence of this protection makes their red blood cells vulnerable to oxidative damage and premature destruction, resulting in hemolytic anemia. High-dose vitamin C can exacerbate this condition by promoting the generation of hydrogen peroxide, causing oxidative damage to hemoglobin and cell membranes. While vitamin C has therapeutic potential, especially in diseases like HIV and hepatitis B, screening for G6PD deficiency is essential before administering high-dose intravenous vitamin C to avoid hemolytic complications.
Does High-Dose Vitamin C Enhance Immunotherapy?
Cancer is a complex disease involving the tumor microenvironment (TME), a diverse ecosystem of cells and molecules. Immunotherapy has shown promise in cancer treatment, but the TME often suppresses the immune system's response. Vitamin C, known for its antioxidant properties, has been studied for its potential anti-cancer effects. Recent research suggests that vitamin C can modulate the TME and enhance immunotherapy. Vitamin C affects various immune cells, promoting T-cell activation and natural killer (NK) cell maturation. It can also reduce immunosuppressive cells like regulatory T-cells and reprogram tumor-associated macrophages. When combined with immunotherapies like checkpoint inhibitors, high-dose vitamin C has shown promise in animal studies, leading to improved tumor response. While more research is needed, vitamin C's immunomodulatory properties may enhance the effectiveness of cancer immunotherapies.
High-Dose Intravenous Vitamin C in Combination with 2-Deoxy Glucose (2DG) for Cancer Treatment
Both intravenous vitamin C (ascorbic acid) and 2-deoxy glucose (2DG) have shown promise in targeting cancer cells. Vitamin C can disrupt the glucose metabolism crucial for tumor cell survival by binding to glucose transporters, limiting glucose uptake, and inducing oxidative stress, leading to cell death. Similarly, 2DG, a glucose analog, interferes with cancer cells' energy production via glycolysis. When these two treatments are combined, they synergistically enhance their effectiveness against cancer. In vitro experiments on breast cancer cell lines demonstrated that the combined therapy reduced tumor size more effectively than individual treatments. In vivo experiments with animal models and human trials also showed promising results, suggesting that this combination therapy could be a potent strategy for various cancer types, with minimal impact on normal cells.
High dose Vitamin C for Cancer Treatment in (...)
In Our Doctor’s Words:
Intravenous (IV) vitamin C (high dose) is an effective integrative approach to target diverse types of cancer and is reported to shrink tumor size and growth. Dr. Mandeep Singh Malhotra (Chief Mentor and Clinical Lead of Art of Healing Cancer, www.artofhealingcancer.com) with his team is going to start treatment of different cancers using high-dose IVC. With more than 20 years of clinical experience, he is a talented and active oncologist. Treatment of different cancers using high doses of IV vitamin C has proven to be beneficial in vitro, in vivo, animal studies and several human clinical trials. So, patients will benefit from this approach because it is more effective in killing cancer cells than conventional therapies, as conventional therapies can develop resistance” said Dr Mandeep Singh Malhotra.
Dr. Mandeep Singh Malhotra
More experienced and highly Qualified Oncologist
More than 20-year experience
Frequently Asked Questions
High-dose Vitamin C therapy involves administering Vitamin C intravenously at higher-than-normal doses. It is believed to have cytotoxic effects on cancer cells and may enhance the effectiveness of conventional cancer treatments.
High-dose Vitamin C therapy has been explored as a complementary treatment for various types of cancer, including breast cancer, pancreatic cancer, lung cancer, and more. It is often used in conjunction with conventional therapies.
High-dose Vitamin C therapy is considered safe when administered by qualified healthcare professionals. However, it may not be suitable for all individuals, and potential side effects should be discussed with your healthcare team.
The dosage of Vitamin C in High-dose Vitamin C therapy is tailored to each patient’s specific needs and medical condition. It is determined by healthcare professionals based on factors like the type and stage of cancer.
High-dose Vitamin C therapy is often used alongside conventional cancer treatments like chemotherapy and radiation therapy. Your healthcare team will carefully plan and monitor your treatment to minimize any potential interactions or side effects.
High-dose Vitamin C therapy is typically used as a complementary treatment alongside conventional cancer therapy. It is essential to discuss your treatment plan with your healthcare team to determine the most suitable approach for your specific case.
