References <\/strong><\/h2>\nAft, R. L., Zhang, F. W., & Gius, D. (2002). Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death. British Journal of Cancer<\/em>, 87<\/em>(7), 805\u2013812. https:\/\/doi.org\/10.1038\/sj.bjc.6600547<\/p>\nArora, K. K., Parry, D. M., & Pedersen, P. L. (1992). Hexokinase receptors: Preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites. Journal of Bioenergetics and Biomembranes<\/em>, 24<\/em>(1), 47\u201353. https:\/\/doi.org\/10.1007\/BF00769530<\/p>\nDagogo-Jack, I., & Shaw, A. T. (2018). Tumour heterogeneity and resistance to cancer therapies. Nature Reviews Clinical Oncology<\/em>, 15<\/em>(2), 81\u201394. https:\/\/doi.org\/10.1038\/nrclinonc.2017.166<\/p>\nHolland, A. J., & Cleveland, D. W. (2009). Boveri revisited: Chromosomal instability, aneuploidy, and tumorigenesis. Nature Reviews Molecular Cell Biology<\/em>, 10<\/em>(7), 478\u2013487. https:\/\/doi.org\/10.1038\/nrm2718<\/p>\nJordan, E. J., Kim, H. R., Arcila, M. E., Barron, D., Chakravarty, D., Gao, J. J., Chang, M. T., Ni, A., Kundra, R., Jonsson, P., Jayakumaran, G., Gao, S. P., Johnsen, H. C., Hanrahan, A. J., Zehir, A., Rekhtman, N., Ginsberg, M. S., Li, B. T., Yu, H. A., \u2026 Riely, G. J. (2017). Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies. Cancer Discovery<\/em>, 7<\/em>(6), 596\u2013609. https:\/\/doi.org\/10.1158\/2159-8290.CD-16-1337<\/p>\nKemper, K., Krijgsman, O., Cornelissen\u2010Steijger, P., Shahrabi, A., Weeber, F., Song, J., Kuilman, T., Vis, D. J., Wessels, L. F., Voest, E. E., Schumacher, T. N., Blank, C. U., Adams, D. J., Haanen, J. B., & Peeper, D. S. (2015). Intra\u2010 and inter\u2010tumor heterogeneity in a vemurafenib\u2010resistant melanoma patient and derived xenografts. EMBO Molecular Medicine<\/em>, 7<\/em>(9), 1104\u20131118. https:\/\/doi.org\/10.15252\/emmm.201404914<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"
Summary Cancer is not a result of a single genetic alteration, but it occurs when there are many mutations in a genome. It does not depend only on the genomic mutations but also on some other factors that stimulate the tumors to result. The genetic alterations vary in different types of cancer and even in […]<\/p>\n","protected":false},"author":1,"featured_media":7847,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"right-sidebar","site-content-layout":"plain-container","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[110],"tags":[43,72,73,71,62,75,76,77,74,78],"acf":[],"_links":{"self":[{"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/posts\/7629"}],"collection":[{"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/comments?post=7629"}],"version-history":[{"count":2,"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/posts\/7629\/revisions"}],"predecessor-version":[{"id":11633,"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/posts\/7629\/revisions\/11633"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/media\/7847"}],"wp:attachment":[{"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/media?parent=7629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/categories?post=7629"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/artofhealingcancer.com\/wp-json\/wp\/v2\/tags?post=7629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}